A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids.
Autor: Galbis-Estrada / C. Mol Vis. 2015 May 11;21:555-67
Ocular Surface and Tear Film Changes in Older Women Working with Computers.
Autor: Ribelles A / Biomed Res Int. 2015;2015:467039. doi: 10.1155/2015/467039
Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628749/pdf/BMRI2015-467039.pdf
Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study.
Autor: Oleñik A / Clin Ophthalmol. 2014;8:169-76
Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888348/pdf/opth-8-169.pdf
Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction.
Autor: Oleñik A / Clin Ophthalmol. 2014 Apr 30;8:831-6
Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010636/pdf/opth-8-831.pdf
Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders.
Autor: Pinazo-Durán MD / Clin Interv Aging. 2013;8:139-48
Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573824/pdf/cia-8-139.pdf
A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction.
Autor: Oleñik A / Clin Interv Aging. 2013;8:1133-8
Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770496/pdf/cia-8-1133.pdf
Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study.
Autor: Gatell-Tortajada J / Clin Interv Aging. 2016 May 19;11:571-8
Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878667/pdf/cia-11-571.pdf
PÁLPEBRAS
Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users.
Authors: María D. Pinazo-Durán, Jorge Raga-Cervera, Silvia M Sanz-González, José Salgado-Borges, Javier Benítez-del-Castillo, Ana I. Ramírez,, Vicente Zanón-Moreno. / Journal of Optometry 2020; 10 pages; https://doi.org/10.1016/j.optom.2019.12.002
Feasibility study of a docosahexaenoic acid optimized nutraceutical Formulation on the macular levels of lutein in a healthy Mediterranean population.
Autor: Zanón-Moreno V., Domingo Pedrol JC, et al; Ophthalmic Research 2020.
Link trial: https://doi.org/10.1159/000509439
Combined intravitreal Ranibizumab and oral supplementation with Docosahexaenoic acid and antioxidants for Diabetic Macular Edema. Two year randomized single-blind controlled trial results (Open Access).
Autor: Lafuente M / (RETINA: July 2017 - Volume 37 - Issue 7 - p 1277–1286)
Three-year outcomes in a randomized single-blind controlled trial of intravitreal ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for diabetic macular edema.
María Lafuente, Lourdes Ortín, María Argente, José L. Guindo, María D. López-Bernal, Francisco J. López-Román, Joan Carles Domingo, Jerónimo Lajara. / RETINA 2019; 39: 1083-1090.
Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry.
María Elena Rodríguez González-Herrero, et al; Clin Ophthalmol 2018; 12:1011-1020.
HEPATOLOGIA
A nutraceutical rich in docosahexaenoic acid improves portal hypertension in a preclinical model of advanced chronic liver disease.
Authors: Zoe Boyer-Diaz, Joan Carles Domingo, Estefanía de Gregorio, Nicolò Manicardi, Peio Aristu-Zabalza, Begoña Cordobilla, Laia Abad-Jordà, Martí Ortega-Ribera, Anabel Fernández-Iglesias, Montserrat Marí, Jaime Bosch and Jordi Gracia-Sancho; Nutrients 2019; 11, 2358; doi: 10.3390/nu11102358.
CULTURAS CELULARES
Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells.
Autor: Bogdanov P / Investigative Ophthalmology & Visual Science May 2008, 49 (13): 5932
Link study: http://iovs.arvojournals.org/article.aspx?articleid=2381313
Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice.
Autor: Pilar mancera et al; Nutrients 2017, 9, 681; doi:10.3390/nu9070681
PÔSTERES
Benefits of oral supplementation with docosahexaenoic acid and antioxidants in pseudoexfoliative glaucoma:
a 6-month open-label randomized controlled trial.
13 European Glaucoma Society Congress, 19-22 May, 2018 Florence, Italy.
Antioxidant/anti-inflammatory effects of a highly-concentrated DHA triglyceride supplement: short, medium and long-term benefits in ophthalmology RCTs.
VITAFOODS EUROPE, 15-17 May, 2018 Geneva, Switzerland.
DÉFICIT DE ATENÇÃO COM HIPERATIVIDADE
Supplementation with High Content Docosahexaenoic Acid Triglyceride in Attention Deficit Hyperactivity Disorder: A Randomized Double-blind Placebo-controlled Trial.
Rodríguez, C.; García, T.; Areces, D., Fernandez, E., García-Noriega, M; Domingo, J.C.
Neuropsychiatric Disease and Treatment, 2019(15), 1193-1209.
Link trial: https://doi.org/10.2147/NDT.S206020
Supplementation with DHA-TG offers oxidative protection on the integrity of the cell’s DNA.
Autor: Jc Martinez-Soto1, Jc Domingo2, B Cordobilla2, LFernandez-PAlbero 1, A Pellicer3 , J Landeras1.1IVI Murcia (Spain),2 Biochemistry and Molecular Biology University of Barcelona (Spain), and 3 IVI Valencia (Spain) Presentado en el 66th Annual Meeting of the ASRM (2010); EFFECT OF DIETARY DHA SUPPLEMENTATION ON SPERM DNA INTEGRITY; Fertility & Sterility 2010; 94:S235-S236.
Download trial fertility & sterility 2010
Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.
Autor: Martinez-Soto JC / Syst Biol Reprod Med. 2016 Oct 28:1-9
Link trial: http://dx.doi.org/10.1080/19396368.2016.1246623
DISTÚRBIOS METABÓLICOS
Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART:
A randomized, double-blind, placebo-controlled study.
Clin Nutr 2017 Jun 8. pii: S0261-5614(17)30214-5. doi: 10.1016/j.clnu.2017.05.032. [Epub ahead of print].
Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study.
Autor: Pere Domingo, et al; Cytokine 105 (2018) 73–79
EXERCÍCIO / ESPORTE
Supplementation of Re-Esterified Docosahexaenoic and Eicosapentaenoic Acids Reduce Inflammatory and Muscle Damage Markers after Exercise in Endurance Athletes: A Randomized, Controlled Crossover Trial; Domingo J. Ramos-Campo, et al; Nutrients 2020, 12, 719; doi:10.3390/nu12030719.
Authors: Domingo J. Ramos-Campo, Vicente Ávila-Gandía, Fco Javier López-Román, José Miñarro, Carlos Contreras, Fulgencio Soto-Méndez, Joan C. Domingo Pedrol and Antonio J. Luque-Rubia.
Oxidative protection of the cell’s DNA and on serum lipid peroxidation, after being exposed to intense physical exercise.
Autor: José A. Villegas et al; Dep. Fisiología; Universidad Católica de San Antonio, Murcia; Comunicación presentada en el 30 Congreso Mundial de Medicina del Deporte; Barcelona, 18-23 Noviembre 2008.
Effect of Docosahexaenoic acid supplementation on difference of endurance exercise performance in competitive and non-competitive male cyclists; Gazzetta Medica Italiana 2019; 178(6):411-6.
Authors: Francisco J. López-Román, Vicente Ávila Gandía, Carlos J. Contreras Fernández, Antonio J. Luque Rubia, José A. Villegas García.
DHA- rich fish oil improves complex reaction time in female elite soccer players; Journal of Sports Science and Medicine (2011) 10, 301-305.
Authors: José F. Guzmán, Hector Esteve, Carlos Pablos, Ana Pablos, Cristina Blasco and José A. Villegas.
PEDIDOS DE BENEFÍCIOS DA EFSA
EFSA and EC approved beneficial claims for HDA.
MONOGRAFIAS CIENTÍFICAS
There is also good news in caring for the diabetic retina. Docosahexaenoic acid (DHA) helps to maintain normal vision This beneficial effect is obtained with a daily intake of DHA 250mg.
Diet supplementation with DHA-triglyceride and antioxidants in patients suffering evaporative Dry Eye.
Triglyceride dietary supplementation with antioxidants DHA* and evaporative dry eye. Our clinical experience.
* Tridocosahexanoína-AOX®.
10 years of basic research on DHA-TG in collaboration with the Biochemistry and Molecular Biology department from the University of Barcelona.
Tridocosahexanoina-AOX®, Scientific fundamentals 2000-2020.
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