Trials & Informs
Vademecum 2024
Glaucoma
Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial.
Authors: Stéphanie Romeo Villadóniga, Elena Rodríguez García, Olatz Sagastagoia Epelde, M. Dolores Álvarez Díaz y Joan Carles Domingo Pedrol.
The Effect of Oral Citicoline and Docosahexaenoic Acid on the Visual Field of Patients with Glaucoma: A Randomized Trial
Authors: Alfonso Anton, Virginia Garcia, Marcos Muñoz, Karla Gonzales, Eleonora Ayala, Estela del Mar Sanchez, Antonio Morilla-Grasa.
Winners Nutra Ingredients Awards for the Nutrition Research Project 2024
Nutrition Research Project: The Effect of Docosahexaenoix Acid Triglyceride (Tridocosahexanoína-AOX®) and Citicoline on the Visual Field of Patients with Glaucoma
Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids.
Autor: C. Galbis-Estrada / Clin Interv Aging. 2013;8:711-9
Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma results of a prospective multicenter study
Author: J. Tellez-Vazquez J / Clin Ophthalmol. 2016 Apr 5;10:617-26
Neuroprotection
Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism.
Authors: Maricel Gómez-Soler, Begoña Cordobilla, Xavier Morató, Víctor Fernández-Dueñas, Joan C. Domingo y Francisco Ciruela.
Ocular surface
A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids.
Authors: Carmen Galbis-Estrada, Maria Dolores Pinazo-Durán, Sebastián Martínez-Castillo, José M. Morales, Daniel Monleón, Vicente Zanon-Moreno
Ocular Surface and Tear Film Changes in Older Women Working with Computers.
Authors: Alfredo Ribelles, Carmen Galbis-Estrada, Maria A. Parras, Bárbara Vivar-Llopis, Carla Marco-Ramírez and Manuel Diaz-Llopis.
Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study.
Author: Andrea Oleñik
Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction.
Authors: Andrea Oleñik, Ignacio Mahillo-Fernández, Nicolás Alejandre-Alba, Guillermo Fernández-Sanz, María Alarcón Pérez, Sol Luxan, Silvia Quintana, Alfonso Martínez de Carneros Llorente, Blanca García-Sandoval, and Ignacio Jiménez-Alfaro.
Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders.
Authors: Maria D Pinazo-Durán,Carmen Galbis-Estrada,Sheila Pons-Vázquez, Jorge Cantú-Dibildox,Carla Marco-Ramírez and Javier Benítez-del-Castillo.
A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction.
Authors: Andrea Oleñik, Ignacio Jiménez-Alfaro,Nicolás Alejandre-Alba and Ignacio Mahillo-Fernández.
Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study.
Author: J. Gatell-Tortajada.
Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study.
Authors: Cristina Peris, José Vicente Piá-Ludeña, María José Rog-Revert, Ester Fernández-López and Joan Carles Domingo.
Eyelids
Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users.
Retina
Feasibility study of a docosahexaenoic acid optimized nutraceutical Formulation on the macular levels of lutein in a healthy Mediterranean population.
Authors: Zanón-Moreno V., Domingo Pedrol J.C., Sanz-González S.M., Raga-Cervera J., Salazar-Corral J., Pinazo-Durán M.D.
Combined intravitreal ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for diabetic macular edema.
Authors: María Lafuente, Md, Lourdes Ortín, Phd, María Argente, Md, José L. Guindo, Phd, María D. López-Bernal, Md, Francisco J. López-Román, Md, Phd, Msc, María J. García, Phd, Juan Carlos Domingo, Phd, Jerónimo Lajara, Md
Three-year outcomes in a randomized single-blind controlled trial of intravitreal ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for diabetic macular edema.
Authors: María Lafuente, Md, Lourdes Ortín, Phd, María Argente, Md, José L. Guindo, Phd, María D. López-Bernal, Md, Francisco J. López-Román, Md, Phd, Msc, María J. García, Phd, Juan Carlos Domingo, Phd, Jerónimo Lajara, Md.
Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry.
Authors: María Elena Rodríguez González-Herrero, Marcos Ruiz, Francisco Javier López Román, José María Marín Sánchez, Joan Carles Domingo
Eye inflammation
Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study.
Authors: Maria D. Pinazo-Durán, Jose J. García-Medina, Silvia M. Sanz-González, Jose E. O’Connor, Ricardo P. Casaroli-Marano, Mar Valero-Velló, Maribel López-Gálvez, Cristina Peris-Martínez, Vicente Zanón-Moreno and Manuel Diaz-Llopis.
Hepatology
A nutraceutical rich in docosahexaenoic acid improves portal hypertension in a preclinical model of advanced chronic liver disease.
Authors: Zoe Boyer-Diaz, Joan Carles Domingo, Estefanía de Gregorio, Nicolò Manicardi, Peio Aristu-Zabalza, Begoña Cordobilla, Laia Abad-Jordà, Martí Ortega-Ribera, Anabel Fernández-Iglesias, Montserrat Marí, Jaime Bosch and Jordi Gracia-Sancho.
Cell cultures
Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells.
Authors: F. Gasso; P. Bogdanov; J. Domingo.
Natural docosahexaenoic acid in the triglyceride form attenuates in vitro microglial activation and ameliorates autoimmune encephalomyelitis in mice.
Authors: Pilar Mancera, Blanca Wappenhans, Begoña Cordobilla, Noemí Virgili Marco Pugliese, Fèlix Rueda, Juan F. Espinosa-Parrilla and Joan C. Domingo.
Posters
Dietary supplementation with high-concentration triglyceride docosahexaenoic acid (DHA) in children and adolescents with ADHD: a randomized, double-blind, placebo-controlled trial.
Authors: Celestino Rodríguez, Trinidad García, Débora Areces, Estrella Fernández, Marcelino García-Noriega, Joan Carles Domingo Pedrol.
Benefits of oral supplementation with docosahexaenoic acid and antioxidants in pseudoexfoliative glaucoma: a 6-month open-label randomized controlled trial.
13 European Glaucoma Society Congress, 19 a 22 de Mayo, 2018 en Florencia, Italia.
Antioxidant/anti-inflammatory effects of a highly-concentrated DHA triglyceride supplement: short, medium and long-term benefits in ophthalmology RCTs..
VITAFOODS EUROPE, el 15 al 17 de Mayo, 2018 en Ginebra, Suiza.
Attention deficit hyperactivity disorder
Supplementation with high-content docosahexaenoic acid triglyceride in attentiondeficit hyperactivity disorder: a randomized double-blind placebo-controlled trial.
Authors: Celestino Rodríguez, Trinidad García, Débora Areces, Estrella Fernández, Marcelino García-Noriega y Joan Carles Domingo.
Fertility
Supplementation with DHA-TG offers oxidative protection on the integrity of the cell’s DNA
Authors: Jc Martinez-Soto, Jc Domingo, B Cordobilla2, LFernandez-PAlbero, A Pellicer, J Landeras IVI Murcia (Spain), Biochemistry and Molecular Biology University of Barcelona (Spain), and IVI Valencia (Spain) Presentado en el 66th Annual Meeting of the ASRM (2010); EFFECT OF DIETARY DHA SUPPLEMENTATION ON SPERM DNA INTEGRITY; Fertility & Sterility 2010; 94:S235-S236.
Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.
Author: Martinez-Soto JC / Syst Biol Reprod Med. 2016 Oct 28:1-9.
Breastfeeding
Inadequate Content of Docosahexaenoic Acid (DHA) of Donor Human Milk for Feeding Preterm Infants: A Comparison with Mother’s Own Milk at Different Stages of Lactation.
Authors: Félix Castillo, Félix-Joel Castillo-Ferrer, Begoña Cordobilla and Joan Carles Domingo.
Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life: A Comparative Study with Infants at Term
Authors: Félix Castillo Salinas, Alicia Montaner Ramón, Félix-Joel Castillo Ferrer, Adrià Domingo-Carnice, Begoña Cordobilla, Joan Carles Domingo.
Metabolic disorders
Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomized, double-blind, placebo-controlled study.
Clin Nutr 2017 Jun 8. pii: S0261-5614(17)30214-5. doi: 10.1016/j.clnu.2017.05.032.
Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study.
Author: Pere Domingo, et al; Cytokine 105 (2018) 73–79.
Changes of Erythrocyte Fatty Acids after Supplementation with Highly Concentrated Docosahexaenoic Acid (DHA) in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial
Author: Dra. Roser Ayats-Vidal, et al; J. Clin. Med. 2023, 12, 3704. https://doi.org/10.3390/jcm12113704
Exercise / Sport
Supplementation of Re-Esterified Docosahexaenoic and Eicosapentaenoic Acids Reduce Inflammatory and Muscle Damage Markers after Exercise in Endurance Athletes.
Authors: Domingo J. Ramos-Campo, Vicente Ávila-Gandía, Fco Javier López-Román, José Miñarro, Carlos Contreras, Fulgencio Soto-Méndez, Joan C. Domingo Pedrol y Antonio J. Luque-Rubia.
Oxidative Stress in Endurance Cycling Is Reduced Dose-Dependently after One Month of Re-Esterified DHA Supplementation.
Authors: Lydia de Salazar, Antonio Torregrosa-García,Antonio J. Luque-Rubia, Vicente Ávila-Gandía, Joan Carles Domingo y F. Javier López-Román.
Effect of Docosahexaenoic acid supplementation on difference of endurance exercise performance in competitive and non-competitive male cyclists; Gazzetta Medica Italiana 2019; 178(6):411-6.
Authors: Francisco J. López-Román, Vicente Ávila Gandía, Carlos J. Contreras Fernández, Antonio J. Luque Rubia, José A. Villegas García.
DHA- rich fish oil improves complex reaction time in female elite soccer players.
Authors: José F. Guzmán, Hector Esteve, Carlos Pablos, Ana Pablos, Cristina Blasco and José A. Villegas
EFSA Complaints
EFSA approves claims that DHA is necessary for normal vision, normal brain function and lowering fasting triglycerides.
Monographs
Clinical cases Blepharitis treated with Brudyitis Monograph.
Monograph: Clinical cases of dry eyes supplemented with DHA triglyceride (Brudysec).
Clinical cases vaginal dryness Brudygyne Dry Monograph.
Clinical efficacy of Brudyderm Dry Eye in palpebral affections due to the use of antiglaucoma drugs.
Authors: María D. Pinazo-Durán, Jorge Raga-Cervera, Silvia M Sanz-González, José Salgado-Borges, Javier Benítez-del-Castillo, Ana I. Ramírez, Vicente Zanón-Moreno