{"id":3202,"date":"2022-07-08T22:10:49","date_gmt":"2022-07-08T22:10:49","guid":{"rendered":"https:\/\/brudylab.net\/?page_id=3202"},"modified":"2025-02-26T07:26:45","modified_gmt":"2025-02-26T07:26:45","slug":"estudios-e-informes","status":"publish","type":"page","link":"https:\/\/brudylab.net\/publica\/estudios-e-informes\/","title":{"rendered":"Estudios e informes"},"content":{"rendered":"[vc_row rt_row_background_width=”fullwidth” rt_row_content_width=”default” rt_row_style=”default-style” rt_row_borders=”” rt_row_shadows=”” rt_row_paddings=”true” rt_bg_effect=”classic” rt_bg_image_repeat=”repeat” rt_bg_size=”cover” rt_bg_position=”right top” rt_bg_attachment=”scroll” rt_bg_video_format=”self-hosted”][vc_column rt_column_shadow=”” rt_bg_image_repeat=”repeat” rt_bg_size=”auto auto” rt_bg_attachment=”scroll”][vc_single_image image=”4737″ img_size=”full” alignment=”center”][vc_column_text]El acceso a los estudios es exclusivo para profesional sanitario.<\/strong><\/span>[\/vc_column_text][vc_btn title=”Acceso profesional sanitario” color=”primary” i_type=”openiconic” add_icon=”true” link=”url:https%3A%2F%2Fbrudylab.net%2Fpublica%2Flogin%2F|title:Acceder|target:_blank”][\/vc_column][\/vc_row][vc_row rt_row_background_width=”fullwidth” rt_row_content_width=”default” rt_row_style=”default-style” rt_row_borders=”” rt_row_shadows=”” rt_column_view=”boxed_columns” rt_row_paddings=”true” rt_bg_effect=”classic” rt_bg_image_repeat=”repeat” rt_bg_size=”cover” rt_bg_position=”right top” rt_bg_attachment=”scroll” rt_bg_video_format=”self-hosted”][vc_column rt_column_shadow=”” rt_bg_image_repeat=”repeat” rt_bg_size=”auto auto” rt_bg_attachment=”scroll” rt_padding_top=”20″ rt_padding_bottom=”20″ rt_padding_left=”20″ rt_padding_right=”20″ rt_bg_color=”” rt_bg_overlay_color=””][vc_column_text]OJO SECO: 1.<\/strong> Pinazo-Dur\u00e1n MD, et al; Effects of a nutraceutical formulation based on the combination of antioxidants and \u03c9-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders; Clinical Int Aging 2013; 8:139-148. 2.<\/strong> Ribelles A, et al; Ocular Surface and Tear Film Changes in Older Women Working with Computers; BioMed Research International 2015; Article ID 467039. 3.<\/strong> Galbis-Estrada C, et al; A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids; Mol Vis. 2015 May 11;21:555-67. 4.<\/strong> Ole\u00f1ik A, et al; A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction; Clinical Interventions in Aging 2013; 8:1133\u201338. 5.<\/strong> Ole\u00f1ik A, et al; Benefits of Omega-3 fatty acid dietary supplementation on health-related quality of life in patients with Meibomian Gland Disfunction; Clinical Ophthalmol 2014; 8:831-836. 6.<\/strong> Gatell-Tortajada J, et al; Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study; Clin Int Aging 2016; 11:571-578. 7.<\/strong> Ole\u00f1ik A, et al; Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study; Clinical Ophthalmology 2014:8 169\u2013176.<\/p>\n

RETINA: 8.<\/strong> Mar\u00eda Lafuente, et al; Combined intravitreal Ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for Diabetic Macular Edema: Two-Year Randomized Single-Blind Controlled Trial Results; Retina 2017; 37:37:1277-1286. 9.<\/strong> Mar\u00eda Elena Rodr\u00edguez, et al; Supplementation with a highly concentrated Docosahexaenoic Acid plus xanthophyll carotenoid multivitamin in nonproliferative Diabetic Retinopathy: Prospective controlled Study of macular function by fundus microperimetry; Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 3, 2017. Clinical Ophthalmology 2018; 12: 1011-1020. 10.<\/strong> Mar\u00eda Lafuente, et al; Intravitreal Ranibizumab combined with docosahexaenoic acid (DHA) dietetic supplementation in diabetic macular edema: 36 months randomized single-blind controlled trial; Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 4, 2017. Retina 2019; 39: 1083-1090. 11.<\/strong> Vicente Zan\u00f3n-Moreno, et al; Feasibility study of a docosahexaenoic acid optimized nutraceutical formulation on the macular levels of lutein in a healthy Mediterranean population; Ophthalmic Research 2020; DOI: 10.1159\/000509439; Published online. 12.<\/strong> P. Pi\u00f1as, et al; Supplementation with a highly concentrated docosahexaenoic acid (DHA) in non-proliferative diabetic retinopathy: a 2-year randomized double-blind placebo-controlled study; Sent to Clinical Ophthalmology 2021.<\/p>\n

GLAUCOMA: 13.<\/strong> Tellez-Vazquez J, et al; Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study; Clin Ophthalmol 2016; 10:617-626. 14.<\/strong> Galbis-Estrada C, et al; Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplement with antioxidants and essential fatty acids; Clin Int Aging 2013; 8:711-9. 15.<\/strong> St\u00e9phanie Romeo, et al; Effects of oral supplementation with Docosahexaenoic acid (DHA) plus antioxidants in Pseudoexfoliative glaucoma: a 6-month open-label randomized trial; Journal of Ophthalmology 2018; Article ID 8259371, 8 pages https:\/\/doi.org\/10.1155\/2018\/8259371. 16.<\/strong> Alfonso Ant\u00f3n, et al; The Effect of Oral Citicoline and Docosahexaenoic Acid on the Visual Field of Patients with Glaucoma: A Randomized Trial;\u00a0<\/span>Life\u00a0<\/span><\/i>2022,\u00a0<\/span>12<\/i>, 1481.\u00a0<\/span><\/span>https:\/\/doi.org\/10.3390\/life12101481. Ganadores Nutra Ingredients Awards for the Nutrition Research Project 2024: The Effect of Docosahexaenoix Acid Triglyceride (Tridocosahexano\u00edna-AOX\u00ae) and Citicoline on the Visual Field of Patients with Glaucoma.<\/a><\/strong><\/span><\/p>\n

INFLAMACI\u00d3N OCULAR: 17. <\/strong>Mar\u00eda Dolores Pinazo-Dur\u00e1n, Manuel D\u00edaz Llopis, et al; Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory effects of DHA-Triglyceride. A pilot study; Diagnostics 2021, 11: 724.<\/p>\n

P\u00c1RPADOS: 18. <\/strong>Mar\u00eda Dolores Pinazo-Dur\u00e1n, et al; Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users; Journal of Optometry 2021; 14:28-36.<\/p>\n

FERTILIDAD: 19.<\/strong> Martinez-Soto JC, et al; Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation; Syst Biol Reprod Med. 2016 Oct 28:1-9. 20.<\/strong> Martinez-Soto JC; Effect of dietary DHA supplementation on sperm DNA integrity; Fertility & Sterility 2010; 94(4):S235-S236 P-495; 21.<\/strong> Popova A Yu, et al, Experience in the use of docosahexaenoic acid (BrudiPlus) in \u0440\u0430ti\u0435\u043fts with increased spenn DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, G\u0443\u043f\u0435\u0441\u043el\u043egy and Perinatology; Andrology & Genital Surgery 2015; 16(2): 51-55.<\/p>\n

DISLIPEMIAS: 22.<\/strong> Pere Domingo, et al; Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomized, double-blind, placebo-controlled study; Clin Nutr. 2018 Aug;37(4):1340-1347. 23.<\/strong> Pere Domingo, et al; Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study; Cytokine 2018; 105:73-79.<\/p>\n

EJERCICIO-DEPORTE: 24. <\/strong>JF Guzman, et al; DHA- rich fish oil improves complex reaction time in female elite soccer players; Journal of Sports Science and Medicine (2011) 10, 301-305. 25.<\/strong> Francisco J. L\u00f3pez-Rom\u00e1n, et al; Effect of Docosahexaenoic acid supplementation on difference of endurance exercise performance in competitive and non-competitive male cyclists; Gazzetta Medica Italiana 2019; 178(6):411-6. 26.<\/strong> Lydia de Salazar, et al; Oxidative Stress in Endurance Cycling Is Reduced Dose-Dependently after One Month of Re-Esterified DHA Supplementation; Antioxidants 2020, 9: 1145; doi:10.3390\/antiox9111145. 27.<\/strong> Domingo J. Ramos-Campo, et al; Supplementation of Re-Esterified Docosahexaenoic and Eicosapentaenoic Acids Reduce Inflammatory and Muscle Damage Markers after Exercise in Endurance Athletes: A Randomized, Controlled Crossover Trial; Nutrients 2020, 12, 719; doi:10.3390\/nu12030719. 28.<\/strong> Vicente \u00c1vila-Gand\u00eda, et al; Re-esterified DHA improves ventilatory threshold 2 in competitive amateur cyclists; Accepted in Journal of the International Society of Sports Nutrition 2020.<\/p>\n

NEUROPEDIATR\u00cdA \/ NEONATOLOG\u00cdA: 29.<\/strong> Celestino Rodr\u00edguez, et al; Supplementation with High Content Docosahexaenoic Acid Triglyceride in Attention Deficit Hyperactivity Disorder: A Randomized Double-Blind Placebo-Controlled Trial; Neuropsychiatric Disease and Treatment 2019; 15: 1193-1209. 30. <\/strong>F\u00e9lix Castillo, et al; Inadequate Content of Docosahexaenoic Acid (DHA) of Donor Human Milk for Feeding Preterm Infants: A Comparison with Mother\u2019s Own Milk at Different Stages of Lactation; Nutrients 2021, 13, 1300.<\/p>\n

CULTIVOS CELULARES Y EXPERIMENTACI\u00d3N ANIMAL: 31. <\/strong>P. Bogdanov, et al; Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells; IOVS, ARVO Journals; May 2008, Vol.49, 5932. doi: 32.<\/strong> Mancera P, et al; Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice; Nutrients 2017, 9, 681; doi:10.3390\/nu9070681. 33.<\/strong> Zoe Boyer-D\u00edaz, et al; A nutraceutical rich in docosahexaenoic acid improves portal hypertension in a preclinical model of advanced chronic liver disease; Nutrients 2019; 11, 2358; doi: 10.3390\/nu11102358. 34.<\/strong> Maricel G\u00f3mez-Soler, et al; Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism; Frontiers in Neuroscience 2018; 12: Article 604.<\/p>\n

ESTUDIOS EN EJECUCI\u00d3N: 35.<\/strong> J. Quintero, et al; evaluaci\u00f3n de la suplementaci\u00f3n con \u00e1cidos grasos omega-3 en pacientes pedi\u00e1tricos con esteatosis hep\u00e1tica no alcoh\u00f3lica. Estudio aleatorizado a doble ciego; en proceso de ejecuci\u00f3n 2022. 36.<\/strong> J. Mora, et al; Interventional openlabel, single arm, institutional study to assess Docosahexaenoic acid triglyceride (DHA-TG) supplementation combined with induction chemotherapy in patients with high-risk neuroblastoma; en proceso de ejecuci\u00f3n 2022. 37.<\/strong> Ayats, et al Efecto del \u00e1cido docosahexaenoico (DHA) antioxidante en pacientes con fibrosis qu\u00edstica. Ensayo clinico aleatorizado doble ciego; finalizado y en redacci\u00f3n para env\u00edo a publicar en 2022. 37.<\/strong> Felix Castillo, et al; Caracterizaci\u00f3n de los niveles de DHA en membrana de eritrocito de grandes prematuros; finalizado y en redacci\u00f3n para env\u00edo a publicar 2022. 39.<\/strong> Cristina Peris, et al; Efecto de la suplementaci\u00f3n con triglic\u00e9rido de DHA en el Queratocono; finalizado y en redacci\u00f3n para env\u00edo a publicar 2022. 40.<\/strong> Antonio Morilla-Grasa, et al; Effect of Citicoline and Docosahexaenoic acid (DHA) in the visual function of glaucoma patients. Preliminary results ARVO Abstracts; Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2402; en proceso de ejecuci\u00f3n 2022.[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

[vc_row rt_row_background_width=”fullwidth” rt_row_content_width=”default” rt_row_style=”default-style” rt_row_borders=”” rt_row_shadows=”” rt_row_paddings=”true” rt_bg_effect=”classic” rt_bg_image_repeat=”repeat” rt_bg_size=”cover” rt_bg_position=”right top” rt_bg_attachment=”scroll” rt_bg_video_format=”self-hosted”][vc_column rt_column_shadow=”” rt_bg_image_repeat=”repeat” rt_bg_size=”auto auto” rt_bg_attachment=”scroll”][vc_single_image image=”4737″ img_size=”full” alignment=”center”][vc_column_text]El acceso a los estudios es exclusivo para profesional sanitario.[\/vc_column_text][vc_btn title=”Acceso profesional sanitario” color=”primary” i_type=”openiconic” add_icon=”true” link=”url:https%3A%2F%2Fbrudylab.net%2Fpublica%2Flogin%2F|title:Acceder|target:_blank”][\/vc_column][\/vc_row][vc_row rt_row_background_width=”fullwidth” rt_row_content_width=”default” rt_row_style=”default-style” rt_row_borders=”” rt_row_shadows=”” rt_column_view=”boxed_columns” rt_row_paddings=”true” rt_bg_effect=”classic” rt_bg_image_repeat=”repeat” rt_bg_size=”cover” rt_bg_position=”right top” rt_bg_attachment=”scroll” rt_bg_video_format=”self-hosted”][vc_column rt_column_shadow=”” rt_bg_image_repeat=”repeat” rt_bg_size=”auto … Continue reading<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-3202","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/pages\/3202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/comments?post=3202"}],"version-history":[{"count":3,"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/pages\/3202\/revisions"}],"predecessor-version":[{"id":6099,"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/pages\/3202\/revisions\/6099"}],"wp:attachment":[{"href":"https:\/\/brudylab.net\/publica\/wp-json\/wp\/v2\/media?parent=3202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}