Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial.

Authors: Stéphanie Romeo Villadóniga, Elena Rodríguez García, Olatz Sagastagoia Epelde, M. Dolores Álvarez Díaz and Joan Carles Domingo Pedrol. Journal of Ophthalmology, Volume 2018, Article ID 8259371, 8 pages.

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Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids.

Autor: Galbis-Estrada C / Clin Interv Aging. 2013;8:711-9

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Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study.

Autor: Tellez-Vazquez J / Clin Ophthalmol. 2016 Apr 5;10:617-26

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Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism.

Authors: Maricel Gómez-Soler, Begoña Cordobilla, Xavier Morató, Víctor Fernández-Dueñas, Joan C. Domingo and Francisco Ciruela. Frontiers of Neuroscience; published: 28 August 2018; doi: 10.3389/fnins.2018.00604.

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A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids.

Autor: Galbis-Estrada / C. Mol Vis. 2015 May 11;21:555-67

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Ocular Surface and Tear Film Changes in Older Women Working with Computers.

Autor: Ribelles A / Biomed Res Int. 2015;2015:467039. doi: 10.1155/2015/467039

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Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study.

Autor: Oleñik A / Clin Ophthalmol. 2014;8:169-76

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Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction.

Autor: Oleñik A / Clin Ophthalmol. 2014 Apr 30;8:831-6

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Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders.

Autor: Pinazo-Durán MD / Clin Interv Aging. 2013;8:139-48

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A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction.

Autor: Oleñik A / Clin Interv Aging. 2013;8:1133-8

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Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study.

Autor: Gatell-Tortajada J / Clin Interv Aging. 2016 May 19;11:571-8

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Diabetic retinopathy

Combined intravitreal Ranibizumab and oral supplementation with Docosahexaenoic acid and antioxidants for Diabetic Macular Edema. Two year randomized single-blind controlled trial results (Open Access).

Autor: Lafuente M / (RETINA: July 2017 - Volume 37 - Issue 7 - p 1277–1286)

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Three-year outcomes in a randomized single-blind controlled trial of intravitreal ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for diabetic macular edema.

María Lafuente, Lourdes Ortín, María Argente, José L. Guindo, María D. López-Bernal, Francisco J. López-Román, Joan Carles Domingo, Jerónimo Lajara. / (RETINA 0:1–8, 2018, ahead of print)

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Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry.

María Elena Rodríguez González-Herrero, et al; Clin Ophthalmol 2018; 12:1011-1020.

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Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells.

Autor: Bogdanov P / Investigative Ophthalmology & Visual Science May 2008, 49 (13): 5932

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Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice.

Autor: Pilar mancera et al; Nutrients 2017, 9, 681; doi:10.3390/nu9070681

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Benefits of oral supplementation with docosahexaenoic acid and antioxidants in pseudoexfoliative glaucoma:
a 6-month open-label randomized controlled trial.

13 European Glaucoma Society Congress, 19-22 May, 2018 Florence, Italy.

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Antioxidant/anti-inflammatory effects of a highly-concentrated DHA triglyceride supplement: short, medium and long-term benefits in ophthalmology RCTs.

VITAFOODS EUROPE, 15-17 May, 2018 Geneva, Switzerland.

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Supplementation with DHA-TG offers oxidative protection on the integrity of the cell’s DNA.

Autor: Jc Martinez-Soto1, Jc Domingo2, B Cordobilla2, LFernandez-PAlbero 1, A Pellicer3 , J Landeras1.1IVI Murcia (Spain),2 Biochemistry and Molecular Biology University of Barcelona (Spain), and 3 IVI Valencia (Spain) Presentado en el 66th Annual Meeting of the ASRM (2010); EFFECT OF DIETARY DHA SUPPLEMENTATION ON SPERM DNA INTEGRITY; Fertility & Sterility 2010; 94:S235-S236.

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Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.

Autor: Martinez-Soto JC / Syst Biol Reprod Med. 2016 Oct 28:1-9

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Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART:
A randomized, double-blind, placebo-controlled study.

Clin Nutr 2017 Jun 8. pii: S0261-5614(17)30214-5. doi: 10.1016/j.clnu.2017.05.032. [Epub ahead of print].

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Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study.

Autor: Pere Domingo, et al; Cytokine 105 (2018) 73–79

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Oxidative protection of the cell’s DNA and on serum lipid peroxidation, after being exposed to intense physical exercise.

Autor: José A. Villegas et al; Dep. Fisiología; Universidad Católica de San Antonio, Murcia; Comunicación presentada en el 30 Congreso Mundial de Medicina del Deporte; Barcelona, 18-23 Noviembre 2008.

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EFSA and EC approved beneficial claims for HDA.

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There is also good news in caring for the diabetic retina. Docosahexaenoic acid (DHA) helps to maintain normal vision This beneficial effect is obtained with a daily intake of DHA 250mg.

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Diet supplementation with DHA-triglyceride and antioxidants in patients suffering evaporative Dry Eye. 
Triglyceride dietary supplementation with antioxidants DHA* and evaporative dry eye. Our clinical experience.

* Tridocosahexanoína-AOX®.

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10 years of basic research on DHA-TG in collaboration with the Biochemistry and Molecular Biology department from the University of Barcelona.

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Tridocosahexaenoin-AOX, Scientific fundamentals 2000-2018.

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