TRIALS & INFORMS

GLAUCOMA

Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids.

Autor: Galbis-Estrada C / Clin Interv Aging. 2013;8:711-9

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693747/pdf/cia-8-711.pdf

 

Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study.

Autor: Tellez-Vazquez J / Clin Ophthalmol. 2016 Apr 5;10:617-26

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827597/pdf/opth-10-617.pdf

DRY EYE

A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids.

Autor: Galbis-Estrada / C. Mol Vis. 2015 May 11;21:555-67

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431415/pdf/mv-v21-555.pdf

 

Ocular Surface and Tear Film Changes in Older Women Working with Computers.

Autor: Ribelles A / Biomed Res Int. 2015;2015:467039. doi: 10.1155/2015/467039

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628749/pdf/BMRI2015-467039.pdf

 

Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study.

Autor: Oleñik A / Clin Ophthalmol. 2014;8:169-76

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888348/pdf/opth-8-169.pdf

 

Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction.

Autor: Oleñik A / Clin Ophthalmol. 2014 Apr 30;8:831-6

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010636/pdf/opth-8-831.pdf

 

Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders.

Autor: Pinazo-Durán MD / Clin Interv Aging. 2013;8:139-48

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573824/pdf/cia-8-139.pdf

 

A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction.

Autor: Oleñik A / Clin Interv Aging. 2013;8:1133-8

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770496/pdf/cia-8-1133.pdf

 

Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study.

Autor: Gatell-Tortajada J / Clin Interv Aging. 2016 May 19;11:571-8

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878667/pdf/cia-11-571.pdf

Diabetic retinopathy

Combined intravitreal Ranibizumab and oral supplementation with Docosahexaenoic acid and antioxidants for Diabetic Macular Edema. Two year randomized single-blind controlled trial results (Open Access).

Autor: Lafuente M / (RETINA: July 2017 - Volume 37 - Issue 7 - p 1277–1286)

Link trial: https://journals.lww.com/retinajournal/fulltext/2017/07000/COMBINED_INTRAVITREAL_RANIBIZUMAB_AND_ORAL.10.aspx

 

Three-year outcomes in a randomized single-blind controlled trial of intravitreal ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for diabetic macular edema.

María Lafuente, Lourdes Ortín, María Argente, José L. Guindo, María D. López-Bernal, Francisco J. López-Román, Joan Carles Domingo, Jerónimo Lajara. / (RETINA 0:1–8, 2018, ahead of print)

Download trial

 

Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry.

María Elena Rodríguez González-Herrero, et al; Clin Ophthalmol 2018; 12:1011-1020.

Download trial

CELULAR CROPS

Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells.

Autor: Bogdanov P / Investigative Ophthalmology & Visual Science May 2008, 49 (13): 5932

Link study: http://iovs.arvojournals.org/article.aspx?articleid=2381313

 

Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice.

Autor: Pilar mancera et al; Nutrients 2017, 9, 681; doi:10.3390/nu9070681

Download trial

POSTERS

Benefits of oral supplementation with docosahexaenoic acid and antioxidants in pseudoexfoliative glaucoma:
a 6-month open-label randomized controlled trial.

13 European Glaucoma Society Congress, 19-22 May, 2018 Florence, Italy.

Download poster

 

Antioxidant/anti-inflammatory effects of a highly-concentrated DHA triglyceride supplement: short, medium and long-term benefits in ophthalmology RCTs.

VITAFOODS EUROPE, 15-17 May, 2018 Geneva, Switzerland.

Download poster

FERTILITY

Supplementation with DHA-TG offers oxidative protection on the integrity of the cell’s DNA.

Autor: Jc Martinez-Soto1, Jc Domingo2, B Cordobilla2, LFernandez-PAlbero 1, A Pellicer3 , J Landeras1.1IVI Murcia (Spain),2 Biochemistry and Molecular Biology University of Barcelona (Spain), and 3 IVI Valencia (Spain) Presentado en el 66th Annual Meeting of the ASRM (2010); EFFECT OF DIETARY DHA SUPPLEMENTATION ON SPERM DNA INTEGRITY; Fertility & Sterility 2010; 94:S235-S236.

Download trial fertility & sterility 2010

 

Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.

Autor: Martinez-Soto JC / Syst Biol Reprod Med. 2016 Oct 28:1-9

Link trial: http://dx.doi.org/10.1080/19396368.2016.1246623

METABOLIC DISORDERS

Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART:
A randomized, double-blind, placebo-controlled study.

Clin Nutr 2017 Jun 8. pii: S0261-5614(17)30214-5. doi: 10.1016/j.clnu.2017.05.032. [Epub ahead of print].

Download clinic trial

 

Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study.

Autor: Pere Domingo, et al; Cytokine 105 (2018) 73–79

Download clinic trial

EXERCISE / SPORT

Oxidative protection of the cell’s DNA and on serum lipid peroxidation, after being exposed to intense physical exercise.

Autor: José A. Villegas et al; Dep. Fisiología; Universidad Católica de San Antonio, Murcia; Comunicación presentada en el 30 Congreso Mundial de Medicina del Deporte; Barcelona, 18-23 Noviembre 2008.

Download clinic trial

EFSA COMPLAINTS

EFSA and EC approved beneficial claims for HDA.

Download clinic trial

SCIENTIFIC MONOGRAPHS

There is also good news in caring for the diabetic retina. Docosahexaenoic acid (DHA) helps to maintain normal vision This beneficial effect is obtained with a daily intake of DHA 250mg.

Download patient tips

 

Diet supplementation with DHA-triglyceride and antioxidants in patients suffering evaporative Dry Eye. 
Triglyceride dietary supplementation with antioxidants DHA* and evaporative dry eye. Our clinical experience.

* Tridocosahexanoína-AOX®.

Download dry eye monography

 

10 years of basic research on DHA-TG in collaboration with the Biochemistry and Molecular Biology department from the University of Barcelona.

Download 10 years monography

 

Tridocosahexaenoin-AOX, Scientific fundamentals 2000-2018.

Download monography

© 2015-2018 Brudy Lab, S.L.U  | C/Ulises 108, 2º C - 28043 Madrid (Spain) - Phone number: +34 91 300 10 14  |  info@brudylab.com  | Legal Notice  |  Cookies  |   Quality policy