TRIALS & INFORMS

GLAUCOMA

Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids.

Autor: Galbis-Estrada C / Clin Interv Aging. 2013;8:711-9

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693747/pdf/cia-8-711.pdf

 

Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study.

Autor: Tellez-Vazquez J / Clin Ophthalmol. 2016 Apr 5;10:617-26

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827597/pdf/opth-10-617.pdf

DRY EYE

A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids.

Autor: Galbis-Estrada / C. Mol Vis. 2015 May 11;21:555-67

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431415/pdf/mv-v21-555.pdf

 

Ocular Surface and Tear Film Changes in Older Women Working with Computers.

Autor: Ribelles A / Biomed Res Int. 2015;2015:467039. doi: 10.1155/2015/467039

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628749/pdf/BMRI2015-467039.pdf

 

Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study.

Autor: Oleñik A / Clin Ophthalmol. 2014;8:169-76

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888348/pdf/opth-8-169.pdf

 

Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction.

Autor: Oleñik A / Clin Ophthalmol. 2014 Apr 30;8:831-6

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010636/pdf/opth-8-831.pdf

 

Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders.

Autor: Pinazo-Durán MD / Clin Interv Aging. 2013;8:139-48

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573824/pdf/cia-8-139.pdf

 

A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction.

Autor: Oleñik A / Clin Interv Aging. 2013;8:1133-8

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770496/pdf/cia-8-1133.pdf

 

Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study.

Autor: Gatell-Tortajada J / Clin Interv Aging. 2016 May 19;11:571-8

Link trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878667/pdf/cia-11-571.pdf

Diabetic retinopathy

Dietetic supplementation of docosahexaenoic acid (DHA) in non proliferative diabetic retinopathy. A prospective controlled study of macular function using microperimetry.

María Elena Rodríguez González-Herrero, Marcos Ruiz, Francisco Javier López-Román, José María Marín Sánchez, Juan Carlos Domingo Pedrol; Communication presented at XXI Congress of the Spanish Society of Retina and Vitreous, Madrid, Friday 3 of Mars, 2017.

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Intravitreal Ranibizumab combined with oral suplementation with docosahexaenoic acid and antioxidants in diabetic macular edema Results at 36 months of a controlled, randomized, simple blinded clinical trial.

María Lafuente, Lourdes Ortín, María Argente, José L. Guindo, María D. López-Bernal, Francisco Javier López-Román, María J. García, Juan Carlos Domingo Pedrol, Jerónimo Lajara; Comunication presented at  XXI Congress of the Spanish Society of Retina and Vitreous,  Madrid, saturday 4 of Mars, 2017.

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Combined intravitreal Ranibizumab and oral supplementation with Docosahexaenoic acid and antioxidants for Diabetic Macular Edema. Two year randomized single-blind controlled trial results (Open Access).

Autor: Lafuente M / Retina. 2016 Oct 26. [Epub ahead of print]

Link trial: http://journals.lww.com/retinajournal/pages/articleviewer.aspx?year=9000&issue=00000&article=97230&type=abstract

CELULAR CROPS

Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells.

Autor: Bogdanov P / Investigative Ophthalmology & Visual Science May 2008, 49 (13): 5932

Link study: http://iovs.arvojournals.org/article.aspx?articleid=2381313

FERTILITY

Supplementation with DHA-TG offers oxidative protection on the integrity of the cell’s DNA.

Autor: Jc Martinez-Soto1, Jc Domingo2, B Cordobilla2, LFernandez-PAlbero 1, A Pellicer3 , J Landeras1.1IVI Murcia (Spain),2 Biochemistry and Molecular Biology University of Barcelona (Spain), and 3 IVI Valencia (Spain) Presentado en el 66th Annual Meeting of the ASRM (2010); EFFECT OF DIETARY DHA SUPPLEMENTATION ON SPERM DNA INTEGRITY; Fertility & Sterility 2010; 94:S235-S236.

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Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.

Autor: Martinez-Soto JC / Syst Biol Reprod Med. 2016 Oct 28:1-9

Link trial: http://dx.doi.org/10.1080/19396368.2016.1246623

EXERCISE / SPORT

Oxidative protection of the cell’s DNA and on serum lipid peroxidation, after being exposed to intense physical exercise.

Autor: José A. Villegas et al; Dep. Fisiología; Universidad Católica de San Antonio, Murcia; Comunicación presentada en el 30 Congreso Mundial de Medicina del Deporte; Barcelona, 18-23 Noviembre 2008.

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EFSA COMPLAINTS

EFSA and EC approved beneficial claims for HDA.

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SCIENTIFIC MONOGRAPHS

There is also good news in caring for the diabetic retina. Docosahexaenoic acid (DHA) helps to maintain normal vision This beneficial effect is obtained with a daily intake of DHA 250mg.

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Diet supplementation with DHA-triglyceride and antioxidants in patients suffering evaporative Dry Eye. 
Triglyceride dietary supplementation with antioxidants DHA* and evaporative dry eye. Our clinical experience.

* Tridocosahexanoína-AOX®.

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10 years of basic research on DHA-TG in collaboration with the Biochemistry and Molecular Biology department from the University of Barcelona.

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Tridocosahexaenoin-AOX, Scientific fundamentals 2000-2016.

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