Clinical experience ophthalmology with Tridocosahexanoin-AOX®.

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Antioxidant Activity and Neuroprotective Role of Docosahexaenoic Acid (DHA) Supplementation in Eye Diseases That Can Lead to Blindness: A Narrative Review.

Authors: María Lafuente, María Elena Rodríguez González-Herrero, Stéphanie Romeo Villadóniga and Joan Carles Domingo.

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Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial.

Authors: Stéphanie Romeo Villadóniga, Elena Rodríguez García, Olatz Sagastagoia Epelde, M. Dolores Álvarez Díaz and Joan Carles Domingo Pedrol. Journal of Ophthalmology, Volume 2018, Article ID 8259371, 8 pages.

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Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids.

Autor: Galbis-Estrada C / Clin Interv Aging. 2013;8:711-9

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Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study.

Autor: Tellez-Vazquez J / Clin Ophthalmol. 2016 Apr 5;10:617-26

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Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism.

Authors: Maricel Gómez-Soler, Begoña Cordobilla, Xavier Morató, Víctor Fernández-Dueñas, Joan C. Domingo and Francisco Ciruela. Frontiers of Neuroscience; published: 28 August 2018; doi: 10.3389/fnins.2018.00604.

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A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids.

Autor: Galbis-Estrada / C. Mol Vis. 2015 May 11;21:555-67

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Ocular Surface and Tear Film Changes in Older Women Working with Computers.

Autor: Ribelles A / Biomed Res Int. 2015;2015:467039. doi: 10.1155/2015/467039

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Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study.

Autor: Oleñik A / Clin Ophthalmol. 2014;8:169-76

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Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction.

Autor: Oleñik A / Clin Ophthalmol. 2014 Apr 30;8:831-6

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Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders.

Autor: Pinazo-Durán MD / Clin Interv Aging. 2013;8:139-48

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A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction.

Autor: Oleñik A / Clin Interv Aging. 2013;8:1133-8

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Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study.

Autor: Gatell-Tortajada J / Clin Interv Aging. 2016 May 19;11:571-8

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Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users.

Authors: María D. Pinazo-Durán, Jorge Raga-Cervera, Silvia M Sanz-González, José Salgado-Borges, Javier Benítez-del-Castillo, Ana I. Ramírez,, Vicente Zanón-Moreno. Journal of Optometry 2020; 10 pages;

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Feasibility study of a docosahexaenoic acid optimized nutraceutical Formulation on the macular levels of lutein in a healthy Mediterranean population.

Autor: Zanón-Moreno V., Domingo Pedrol JC, et al;  Ophthalmic Research 2020.

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Combined intravitreal Ranibizumab and oral supplementation with Docosahexaenoic acid and antioxidants for Diabetic Macular Edema. Two year randomized single-blind controlled trial results (Open Access).

Autor: Lafuente M / (RETINA: July 2017 - Volume 37 - Issue 7 - p 1277–1286)

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Three-year outcomes in a randomized single-blind controlled trial of intravitreal ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for diabetic macular edema.

María Lafuente, Lourdes Ortín, María Argente, José L. Guindo, María D. López-Bernal, Francisco J. López-Román, Joan Carles Domingo, Jerónimo Lajara. / RETINA 2019; 39: 1083-1090.

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Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin in nonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry.

María Elena Rodríguez González-Herrero, et al; Clin Ophthalmol 2018; 12:1011-1020.

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Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of

DHA-Triglyceride. A Pilot Study.

Authors: Maria D. Pinazo-Durán, Jose J. García-Medina, Silvia M. Sanz-González, Jose E. O’Connor, Ricardo P. Casaroli-Marano, Mar Valero-Velló, Maribel López-Gálvez, Cristina Peris-Martínez, Vicente Zanón-Moreno and Manuel Diaz-Llopis.

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A nutraceutical rich in docosahexaenoic acid improves portal hypertension in a preclinical model of advanced chronic liver disease.

Authors: Zoe Boyer-Diaz, Joan Carles Domingo, Estefanía de Gregorio, Nicolò Manicardi, Peio Aristu-Zabalza, Begoña Cordobilla, Laia Abad-Jordà, Martí Ortega-Ribera, Anabel Fernández-Iglesias, Montserrat Marí, Jaime Bosch and Jordi Gracia-Sancho; Nutrients 2019; 11, 2358; doi: 10.3390/nu11102358.

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Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells.

Autor: Bogdanov P / Investigative Ophthalmology & Visual Science May 2008, 49 (13): 5932

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Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice.

Autor: Pilar mancera et al; Nutrients 2017, 9, 681; doi:10.3390/nu9070681

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Benefits of oral supplementation with docosahexaenoic acid and antioxidants in pseudoexfoliative glaucoma:
a 6-month open-label randomized controlled trial.

13 European Glaucoma Society Congress, 19-22 May, 2018 Florence, Italy.

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Antioxidant/anti-inflammatory effects of a highly-concentrated DHA triglyceride supplement: short, medium and long-term benefits in ophthalmology RCTs.

VITAFOODS EUROPE, 15-17 May, 2018 Geneva, Switzerland.

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Supplementation with high-content docosahexaenoic acid triglyceride in attentiondeficit hyperactivity disorder: a randomized double-blind placebo-controlled trial.

Authors: Celestino Rodríguez, Trinidad García, Débora Areces, Estrella Fernández, Marcelino García-Noriega and Joan Carles Domingo.

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Supplementation with DHA-TG offers oxidative protection on the integrity of the cell’s DNA.

Autor: Jc Martinez-Soto1, Jc Domingo2, B Cordobilla2, LFernandez-PAlbero 1, A Pellicer3 , J Landeras1.1IVI Murcia (Spain),2 Biochemistry and Molecular Biology University of Barcelona (Spain), and 3 IVI Valencia (Spain) Presentado en el 66th Annual Meeting of the ASRM (2010); EFFECT OF DIETARY DHA SUPPLEMENTATION ON SPERM DNA INTEGRITY; Fertility & Sterility 2010; 94:S235-S236.

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Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.

Autor: Martinez-Soto JC / Syst Biol Reprod Med. 2016 Oct 28:1-9

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Inadequate Content of Docosahexaenoic Acid (DHA) of Donor Human Milk for Feeding Preterm Infants: A Comparison with Mother’s Own Milk at Different Stages of Lactation.

Authors: Félix Castillo, Félix-Joel Castillo-Ferrer, Begoña Cordobilla and Joan Carles Domingo.

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Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART:
A randomized, double-blind, placebo-controlled study.

Clin Nutr 2017 Jun 8. pii: S0261-5614(17)30214-5. doi: 10.1016/j.clnu.2017.05.032. [Epub ahead of print].

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Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study.

Autor: Pere Domingo, et al; Cytokine 105 (2018) 73–79

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Supplementation of Re-Esterified Docosahexaenoic and Eicosapentaenoic Acids Reduce Inflammatory and Muscle Damage Markers after Exercise in Endurance Athletes: A Randomized, Controlled Crossover Trial; Domingo J. Ramos-Campo, et al; Nutrients 2020, 12, 719; doi:10.3390/nu12030719.

Authors: Domingo J. Ramos-Campo, Vicente Ávila-Gandía, Fco Javier López-Román, José Miñarro, Carlos Contreras, Fulgencio Soto-Méndez, Joan C. Domingo Pedrol and Antonio J. Luque-Rubia.

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Oxidative Stress in Endurance Cycling Is Reduced Dose-Dependently after One Month of Re-Esterified

DHA Supplementation.

Authors: Lydia de Salazar, Antonio Torregrosa-García, Antonio J. Luque-Rubia, Vicente Ávila-Gandía, Joan Carles Domingo and F. Javier López-Román.

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Effect of Docosahexaenoic acid supplementation on difference of endurance exercise performance in competitive and non-competitive male cyclists; Gazzetta Medica Italiana 2019; 178(6):411-6.

Authors: Francisco J. López-Román, Vicente Ávila Gandía, Carlos J. Contreras Fernández, Antonio J. Luque Rubia, José A. Villegas García.

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DHA- rich fish oil improves complex reaction time in female elite soccer players; Journal of Sports Science and Medicine (2011) 10, 301-305.

Authors: José F. Guzmán, Hector Esteve, Carlos Pablos, Ana Pablos, Cristina Blasco and José A. Villegas.

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EFSA and EC approved beneficial claims for HDA.

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There is also good news in caring for the diabetic retina. Docosahexaenoic acid (DHA) helps to maintain normal vision This beneficial effect is obtained with a daily intake of DHA 250mg.

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