Pinazo-Durán MD, et al; Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders; Clinical Int Aging 2013; 8:139-148.
Galbis-Estrada C, et al; Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surfacedisorder to oral supplement with antioxidants and essential fatty acids; Clin Int Aging 2013;8:711-9 *También en el apartado de GLAUCOMA
Oleñik A, Jiménez-Alfaro I, Alejandre-Alba N, Mahillo-Fernández I. A randomized, double-masked study to evaluate the effect of omega-3 fatty acidssupplementation in meibomian gland dysfunction. Clin Interv Aging. 2013;8:1133-8. doi: 10.2147/CIA.S48955. Epub 2013 Aug 30. PMID: 24039409; PMCID:PMC3770496.
Oleñik A, et al; Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study; Clinical Ophthalmology 2014:8 169-176
Oleñik A, et al; Benefits of Omega-3 fatty acid dietary supplementation on health-related quality of life in patients with Meibomian Gland Disfunction;Clinical Ophthalmol 2014; 8:831-836.
Ribelles A, et al; Ocular Surface and Tear Film Changes in Older Women Working with Computers; BioMed Research International 2015; Article ID 467039
Galbis-Estrada C, et al; A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids; Mol Vis.2015 May 11;21:555-67
Gatell-Tortajada J, et al; Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in alarge series of patients with dry eye symptoms: results of a prospective study; Clin Int Aging 2016; 11:571-578
Tellez-Vazquez J, et al; Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenterstudy; Clin Ophthalmol 2016; 10:617-626. *También en el apartado de GLAUCOMA

RETINA

Lafuente M, Ortín L, Argente M, Guindo JL, López-Bernal MD, López-Román FJ, García MJ, Domingo JC, Lajara J. COMBINED INTRAVITREAL RANIBIZUMAB AND ORAL SUPPLEMENTATION WITHDOCOSAHEXAENOIC ACID AND ANTIOXIDANTS FOR DIABETIC MACULAR EDEMA: Two-Year Randomized Single-Blind Controlled Trial Results. Retina. 2017 Jul;37(7):1277-1286. doi:10.1097/IAE.0000000000001363. PMID: 27787443.
Rodríguez González-Herrero ME, Ruiz M, López Román FJ, Marín Sánchez JM, Domingo JC. Supplementation with a highly concentrated docosahexaenoic acid plus xanthophyll carotenoid multivitamin innonproliferative diabetic retinopathy: prospective controlled study of macular function by fundus microperimetry. Clin Ophthalmol. 2018 May 29;12:1011-1020. doi: 10.2147/OPTH.S157635. PMID:29881256; PMCID: PMC5983010.
Lafuente M, Ortín L, Argente M, Guindo JL, López-Bernal MD, López-Román FJ, Domingo JC, Lajara J. THREE-YEAR OUTCOMES IN A RANDOMIZED SINGLE-BLIND CONTROLLED TRIAL OF INTRAVITREALRANIBIZUMAB AND ORAL SUPPLEMENTATION WITH DOCOSAHEXAENOIC ACID AND ANTIOXIDANTS FOR DIABETIC MACULAR EDEMA. Retina. 2019 Jun;39(6):1083-1090. doi:10.1097/IAE.0000000000002114. PMID: 29474306; PMCID: PMC6553973.
Zanón-Moreno V, Domingo Pedrol JC, Sanz-González SM, Raga-Cervera J, Salazar-Corral J, Pinazo-Durán MD. Feasibility Study of a Docosahexaenoic Acid-Optimized Nutraceutical Formulation on theMacular Levels of Lutein in a Healthy Mediterranean Population. Ophthalmic Res. 2021;64(6):1068-1076. doi: 10.1159/000509439. Epub 2020 Jun 16. PMID: 32544914; PMCID: PMC8743924.
Piñas García P, Hernández Martínez FJ, Aznárez López N, Castillón Torre L, Tena Sempere ME. Supplementation with a Highly Concentrated Docosahexaenoic Acid (DHA) in Non-Proliferative DiabeticRetinopathy: A 2-Year Randomized Double-Blind Placebo-Controlled Study. Antioxidants (Basel). 2022 Jan 5;11(1):116. doi: 10.3390/antiox11010116. PMID: 35052620; PMCID: PMC8772895.

Comunicaciones:

María Elena Rodríguez, et al; Supplementation with a highly concentrated Docosahexaenoic Acid plus xanthophyll carotenoid multivitamin in nonproliferative Diabetic Retinopathy: Prospective controlledStudy of macular function by fundus microperimetry; Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 3, 2017. Clinical Ophthalmology 2018; 12:1011-1020.
María Lafuente, et al; Intravitreal Ranibizumab combined with docosahexae- noic acid (DHA) dietetic supplementation in diabetic macular edema: 36 months randomized single-blind controlled trial;Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 4, 2017. Retina 2019; 39: 1083-1090.

Revisiones:

Abreu-González R, Díaz-Rodríguez R, Abreu-Reyes JA. Nutritional supplements with omega 3 in retinal disease: Relationship between volume and concentration in commercial products. Arch Soc EspOftalmol (Engl Ed). 2018 Dec;93(12):592-597. English, Spanish. doi: 10.1016/j.oftal.2018.05.015. Epub 2018 Jul 17. PMID: 30025989.
Lafuente M, Rodríguez González-Herrero ME, Romeo Villadóniga S, Domingo JC. Antioxidant Activity and Neuroprotective Role of Docosahexaenoic Acid (DHA) Supplementation in Eye Diseases That CanLead to Blindness: A Narrative Review. Antioxidants (Basel). 2021 Mar 5;10(3):386. doi: 10.3390/antiox10030386. PMID: 33807538; PMCID: PMC8000043.

GLAUCOMA

Galbis-Estrada C, et al; Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplement with antioxidants and essential fatty acids; Clin Int Aging 2013;8:711-9
Tellez-Vazquez J, et al; Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenterstudy; Clin Ophthalmol 2016; 10:617-626.
Stéphanie Romeo; Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial. Communication Poster at Congress of European Glaucoma Society, Florence, May 20, 2018. Published in Journal of Ophthalmology, Volume 2018, Article ID 8259371, 8 pages; https://doi.org/10.1155/2018/8259371
Anton A, Garcia V, Muñoz M, Gonzales K, Ayala E, Del Mar Sanchez E, Morilla-Grasa A. The Effect of Oral Citicoline and Docosahexaenoic Acid on the VisualField of Patients with Glaucoma: A Randomized Trial. Life (Basel). 2022 Sep 23;12(10):1481. doi: 10.3390/life12101481. PMID: 36294916; PMCID:PMC9604833.

Pósters/Comunicaciones:

Antonio Morilla-Grasa, et al; Effect of Citicoline and Docosahexaenoic acid (DHA) in the visual function of glaucoma patients. Preliminary results ARVO Abstracts; Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2402
Hernández-Barahona Monleón, C., Fernández Velasco, D., Ferrández Arenas, B., Bambó Rubio, M. P., Pérez Oliván, S., & Güerri Monclus, N. (2025). Sinergismo entre DHA y Netarsudil. Congreso Sociedad Española de Glaucoma 2025. San Sebastián, España. Hospital Universitario Miguel Servet, Zaragoza

UVEITIS

Pinazo-Durán MD, García-Medina JJ, Sanz-González SM, O'Connor JE, Casaroli-Marano RP, Valero-Velló M, López-Gálvez M, Peris-Martínez C, Zanón-Moreno V, Diaz-Llopis M. Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory Effects of DHA-Triglyceride. A Pilot Study. Diagnostics (Basel). 2021 Apr 19;11(4):724. doi: 10.3390/diagnostics11040724. PMID: 33921773; PMCID: PMC8072877.

QUERATOCONO

Peris-Martínez C, Piá-Ludeña JV, Rog-Revert MJ, Fernández-López E, Domingo JC. Antioxidant and Anti-Inflammatory Effects of Oral Supplementation with a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients with Keratoconus: A Randomized Controlled Preliminary Study. Nutrients. 2023 Mar 6;15(5):1300. doi: 10.3390/nu15051300. PMID: 36904299; PMCID: PMC10005296.

TOPICO

Pinazo-Durán MD, Raga-Cervera J, Sanz-González SM, Salgado-Borges J, Benítez-Del-Castillo J, Ramírez AI, Zanón-Moreno V. Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users. J Optom. 2021 Jan-Mar;14(1):28-36. doi: 10.1016/j.optom.2019.12.002. Epub 2020 Apr 19. PMID: 32317229; PMCID: PMC7752988.

NIÑOS

ADHD

Rodríguez C, García T, Areces D, Fernández E, García-Noriega M, Domingo JC. Supplementation with high-content docosahexaenoic acid triglyceride in attention-deficit hyperactivity disorder: a randomized double-blind placebo-controlled trial. Neuropsychiatr Dis Treat. 2019 May 8;15:1193-1209. doi: 10.2147/NDT.S206020. PMID: 31190827; PMCID: PMC6514260.

FIBROSIS QUÍSTICA

Ayats-Vidal R, Bosque-García M, Cordobilla B, Asensio-De la Cruz O, García-González M, Castro-Marrero J, López-Rico I, Domingo JC. Changes of Erythrocyte Fatty Acids after Supplementation with Highly Concentrated Docosahexaenoic Acid (DHA) in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial. J Clin Med. 2023 May 26;12(11):3704. doi: 10.3390/jcm12113704. PMID: 37297899; PMCID: PMC10253750.
Ayats-Vidal R, Bosque-García M, Cordobilla B, Asensio-De la Cruz O, García-González M, Loureda-Pérez S, Fernández-López E, Robert-Barriocanal E, Valiente-Planas A, Domingo JC. Impact of 1-Year Supplementation with High-Rich Docosahexaenoic Acid (DHA) on Clinical Variables and Inflammatory Biomarkers in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial. Nutrients. 2024 Mar 27;16(7):970. doi: 10.3390/nu16070970. PMID: 38613004; PMCID: PMC11013158.

NEONATOLOGIA (sobre DHA)

Castillo F, Castillo-Ferrer FJ, Cordobilla B, Domingo JC. Inadequate Content of Docosahexaenoic Acid (DHA) of Donor Human Milk for Feeding Preterm Infants: A Comparison with Mother's Own Milk at Different Stages of Lactation. Nutrients. 2021 Apr 15;13(4):1300. doi: 10.3390/nu13041300. PMID: 33920807; PMCID: PMC8071120.
Castillo Salinas F, Montaner Ramón A, Castillo Ferrer FJ, Domingo-Carnice A, Cordobilla B, Domingo JC. Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life: A Comparative Study with Infants at Term. Nutrients. 2022 Nov 22;14(23):4956. doi: 10.3390/nu14234956. PMID: 36500985; PMCID: PMC9740272.

FERTILIDAD

Martinez-Soto JC; Effect of dietary DHA supplementation on sperm DNA integrity; Fertility & Sterility 2010; 94(4):S235-S236 P-495;
Popova A Yu, et al, Experience in the use of docosahexaenoic acid (BrudyPlus) in patients with increased sperm DNA fragmentation index in Acad. V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology; Andrology & Genital Surgery 2015; 16(2): 51-55.
Vinogradov I.V., Gamidov S.I., Gabliya M.Yu., Zhukov O.B., Ovchinnikov R.I., Malinina O.Yu., Popova A.Yu., Chaly M.E., Bragina E.E., Zhivulko A.R.(2019). Docosahexaenoic Acid in the Treatment of Idiopathic Forms of Male Infertility. Urology, 2019(1):00-00. [DOI:https://dx.doi.org/10.18565/urology.2019.16.00-00]
Martinez-Soto JC, et al; Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNAfragmentation; Syst Biol Reprod Med. 2016 Oct 28:1-9.

DEPORTE

JF Guzman, et al; DHA- rich fish oil improves complex reaction time in female elite soccer players; Journal of Sports Science and Medicine (2011) 10, 301-305.
Carlos J Contreras; Modificación del daño oxidativo en un grupo de ciclistas tras consumir ácido docosahexaenoico a distintas dosis; Tesis Doctoral, Universidad Católica de Murcia, 2014
Francisco J. López-Román, et al; Effect of Docosahexaenoic acid supplementation on difference of endurance exercise performance in competitive andnon-competitive male cyclists; Gazzetta Medica Italiana 2019; 178(6):411-6.
Lydia de Salazar, et al; Oxidative Stress in Endurance Cycling Is Reduced Dose-Dependently after One Month of Re-Esterified DHA Supplementation;Antioxidants 2020, 9: 1145; doi:10.3390/antiox9111145.
Domingo J. Ramos-Campo, et al; Supplementation of Re-Esterified Docosahexaenoic and Eicosapentaenoic Acids Reduce Inflammatory and MuscleDamage Markers after Exercise in Enduran- ce Athletes: A Randomized, Controlled Crossover Trial; Nutrients 2020, 12, 719; doi:10.3390/nu12030719.
Vicente Ávila-Gandía, et al; Re-esterified DHA improves ventilatory threshold 2 in competitive amateur cyclists; Accepted in Journal of the International Society of Sports Nutrition 2020.

Comunicaciones:

José A. Villegas et al; Dep. Fisiología; Universidad Católica de San Antonio, Murcia; Protección del daño oxidativo en el DNA tras el ejercicio intenso;Comunicación presentada en el 30 Congreso Mundial de Medicina del Deporte; Barcelona, 18-23 Noviembre 2008.

TRANSTORNO METABOLISMO LIPÍDICO

Pere Domingo, et al; Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomi- zed, double-blind, placebo-controlled study; Clin Nutr. 2018 Aug;37(4):1340-1347.
Pere Domingo, et al; Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infectedpatients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study; Cytokine 2018; 105:73-79.
Zoe Boyer-Díaz, et al; A nutraceutical rich in docosahexaenoic acid improves portal hypertension in a preclinical model of advanced chronic liver disease;Nutrients 2019; 11, 2358; doi: 10.3390/nu11102358.

Revisiones:

Boyer-Diaz Z, Morata P, Aristu-Zabalza P, Gibert-Ramos A, Bosch J, Gracia-Sancho J. Oxidative Stress in Chronic Liver Disease and Portal Hypertension:Potential of DHA as Nutraceutical. Nutrients. 2020 Aug 28;12(9):2627. doi: 10.3390/nu12092627. PMID: 32872239; PMCID: PMC7551786.
Mora I, Puiggròs F, Serras F, Gil-Cardoso K, Escoté X. Emerging models for studying adipose tissue metabolism. Biochem Pharmacol. 2024May;223:116123. doi: 10.1016/j.bcp.2024.116123. Epub 2024 Mar 12. PMID: 38484851.

NEUROLOGIA

Mancera P, et al; Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice; Nutrients 2017, 9, 681; doi:10.3390/nu9070681.
Maricel Gómez-Soler, et al; Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism; Frontiers in Neuroscience 2018; 12: Article 604.
Mora I, Arola L, Caimari A, Escoté X, Puiggròs F. Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging. Int J MolSci. 2022 Mar 23;23(7):3472. doi: 10.3390/ijms23073472. PMID: 35408832; PMCID: PMC8998232.

Comunicación:

Romero, Elisabet & Virgili, Nuria & Barceló, M. & Povedano, Monica & Domingo, J.C.. (2017). SUN-P178: Oral Supplementation with the Omega-3 Docosahexaenoic Acid (DHA) in Patients with Amyotrophic Lateral Sclerosis (ALS): A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Clinical Nutrition. 36. S119-S120. 10.1016/S0261-5614(17)30450-8.

IN VITRO

POSTER ORIGINAL:

Bogdanov, et al; Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells; IOVS, ARVO Journals; May 2008, Vol.49, 5932. doi:

Artículos:

Dolz-Marco R, Gallego-Pinazo R, Pinazo-Duran MD, Pons-Vázquez S, Domingo-Pedro JC, Díaz-Llopis M. Intravitreal docosahexaenoic acid in a rabbit model: preclinical safety assessment. PLoS One. 2014 May 8;9(5):e96872. doi: 10.1371/journal.pone.0096872. PMID: 24809445; PMCID: PMC4014583.
Mora I, Pérez-Santamaria A, Tortajada-Pérez J, Vázquez-Manrique RP, Arola L, Puiggròs F. Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans. Cells. 2023 Jul 26;12(15):1932. doi: 10.3390/cells12151932. PMID: 37566010; PMCID: PMC10417004.
Mora I, Teixidó A, Vázquez-Manrique RP, Puiggròs F, Arola L. Docosahexaenoic Acid (DHA) Supplementation in a Triglyceride Form Prevents from Polyglutamine-Induced Dysfunctions in Caenorhabditis elegans. Int J Mol Sci. 2024 Nov 23;25(23):12594. doi: 10.3390/ijms252312594. PMID: 39684306; PMCID: PMC11640917.