Estudios e informes

OJO SECO: 1. Pinazo-Durán MD, et al; Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders; Clinical Int Aging 2013; 8:139-148. 2. Ribelles A, et al; Ocular Surface and Tear Film Changes in Older Women Working with Computers; BioMed Research International 2015; Article ID 467039. 3. Galbis-Estrada C, et al; A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids; Mol Vis. 2015 May 11;21:555-67. 4. Oleñik A, et al; A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction; Clinical Interventions in Aging 2013; 8:1133–38. 5. Oleñik A, et al; Benefits of Omega-3 fatty acid dietary supplementation on health-related quality of life in patients with Meibomian Gland Disfunction; Clinical Ophthalmol 2014; 8:831-836. 6. Gatell-Tortajada J, et al; Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study; Clin Int Aging 2016; 11:571-578. 7. Oleñik A, et al; Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study; Clinical Ophthalmology 2014:8 169–176.

RETINA: 8. María Lafuente, et al; Combined intravitreal Ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for Diabetic Macular Edema: Two-Year Randomized Single-Blind Controlled Trial Results; Retina 2017; 37:37:1277-1286. 9. María Elena Rodríguez, et al; Supplementation with a highly concentrated Docosahexaenoic Acid plus xanthophyll carotenoid multivitamin in nonproliferative Diabetic Retinopathy: Prospective controlled Study of macular function by fundus microperimetry; Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 3, 2017. Clinical Ophthalmology 2018; 12: 1011-1020. 10. María Lafuente, et al; Intravitreal Ranibizumab combined with docosahexaenoic acid (DHA) dietetic supplementation in diabetic macular edema: 36 months randomized single-blind controlled trial; Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 4, 2017. Retina 2019; 39: 1083-1090. 11. Vicente Zanón-Moreno, et al; Feasibility study of a docosahexaenoic acid optimized nutraceutical formulation on the macular levels of lutein in a healthy Mediterranean population; Ophthalmic Research 2020; DOI: 10.1159/000509439; Published online. 12. P. Piñas, et al; Supplementation with a highly concentrated docosahexaenoic acid (DHA) in non-proliferative diabetic retinopathy: a 2-year randomized double-blind placebo-controlled study; Sent to Clinical Ophthalmology 2021.

GLAUCOMA: 13. Tellez-Vazquez J, et al; Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study; Clin Ophthalmol 2016; 10:617-626. 14. Galbis-Estrada C, et al; Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplement with antioxidants and essential fatty acids; Clin Int Aging 2013; 8:711-9. 15. Stéphanie Romeo, et al; Effects of oral supplementation with Docosahexaenoic acid (DHA) plus antioxidants in Pseudoexfoliative glaucoma: a 6-month open-label randomized trial; Journal of Ophthalmology 2018; Article ID 8259371, 8 pages https://doi.org/10.1155/2018/8259371. 16. Alfonso Antón, et al; The Effect of Oral Citicoline and Docosahexaenoic Acid on the Visual Field of Patients with Glaucoma: A Randomized Trial; Life 2022, 12, 1481. https://doi.org/10.3390/life12101481. Ganadores Nutra Ingredients Awards for the Nutrition Research Project 2024: The Effect of Docosahexaenoix Acid Triglyceride (Tridocosahexanoína-AOX®) and Citicoline on the Visual Field of Patients with Glaucoma.

INFLAMACIÓN OCULAR: 17. María Dolores Pinazo-Durán, Manuel Díaz Llopis, et al; Signature of Circulating Biomarkers in Recurrent Non-Infectious Anterior Uveitis. Immunomodulatory effects of DHA-Triglyceride. A pilot study; Diagnostics 2021, 11: 724.

PÁRPADOS: 18. María Dolores Pinazo-Durán, et al; Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users; Journal of Optometry 2021; 14:28-36.

FERTILIDAD: 19. Martinez-Soto JC, et al; Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation; Syst Biol Reprod Med. 2016 Oct 28:1-9. 20. Martinez-Soto JC; Effect of dietary DHA supplementation on sperm DNA integrity; Fertility & Sterility 2010; 94(4):S235-S236 P-495; 21. Popova A Yu, et al, Experience in the use of docosahexaenoic acid (BrudiPlus) in раtiепts with increased spenn DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gупесоlоgy and Perinatology; Andrology & Genital Surgery 2015; 16(2): 51-55.

DISLIPEMIAS: 22. Pere Domingo, et al; Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomized, double-blind, placebo-controlled study; Clin Nutr. 2018 Aug;37(4):1340-1347. 23. Pere Domingo, et al; Effects of docosahexanoic acid supplementation on inflammatory and subcutaneous adipose tissue gene expression in HIV-infected patients on combination antiretroviral therapy (cART). A sub-study of a randomized, double-blind, placebo-controlled study; Cytokine 2018; 105:73-79.

EJERCICIO-DEPORTE: 24. JF Guzman, et al; DHA- rich fish oil improves complex reaction time in female elite soccer players; Journal of Sports Science and Medicine (2011) 10, 301-305. 25. Francisco J. López-Román, et al; Effect of Docosahexaenoic acid supplementation on difference of endurance exercise performance in competitive and non-competitive male cyclists; Gazzetta Medica Italiana 2019; 178(6):411-6. 26. Lydia de Salazar, et al; Oxidative Stress in Endurance Cycling Is Reduced Dose-Dependently after One Month of Re-Esterified DHA Supplementation; Antioxidants 2020, 9: 1145; doi:10.3390/antiox9111145. 27. Domingo J. Ramos-Campo, et al; Supplementation of Re-Esterified Docosahexaenoic and Eicosapentaenoic Acids Reduce Inflammatory and Muscle Damage Markers after Exercise in Endurance Athletes: A Randomized, Controlled Crossover Trial; Nutrients 2020, 12, 719; doi:10.3390/nu12030719. 28. Vicente Ávila-Gandía, et al; Re-esterified DHA improves ventilatory threshold 2 in competitive amateur cyclists; Accepted in Journal of the International Society of Sports Nutrition 2020.

NEUROPEDIATRÍA / NEONATOLOGÍA: 29. Celestino Rodríguez, et al; Supplementation with High Content Docosahexaenoic Acid Triglyceride in Attention Deficit Hyperactivity Disorder: A Randomized Double-Blind Placebo-Controlled Trial; Neuropsychiatric Disease and Treatment 2019; 15: 1193-1209. 30. Félix Castillo, et al; Inadequate Content of Docosahexaenoic Acid (DHA) of Donor Human Milk for Feeding Preterm Infants: A Comparison with Mother’s Own Milk at Different Stages of Lactation; Nutrients 2021, 13, 1300.

CULTIVOS CELULARES Y EXPERIMENTACIÓN ANIMAL: 31. P. Bogdanov, et al; Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells; IOVS, ARVO Journals; May 2008, Vol.49, 5932. doi: 32. Mancera P, et al; Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice; Nutrients 2017, 9, 681; doi:10.3390/nu9070681. 33. Zoe Boyer-Díaz, et al; A nutraceutical rich in docosahexaenoic acid improves portal hypertension in a preclinical model of advanced chronic liver disease; Nutrients 2019; 11, 2358; doi: 10.3390/nu11102358. 34. Maricel Gómez-Soler, et al; Triglyceride Form of Docosahexaenoic Acid Mediates Neuroprotection in Experimental Parkinsonism; Frontiers in Neuroscience 2018; 12: Article 604.

ESTUDIOS EN EJECUCIÓN: 35. J. Quintero, et al; evaluación de la suplementación con ácidos grasos omega-3 en pacientes pediátricos con esteatosis hepática no alcohólica. Estudio aleatorizado a doble ciego; en proceso de ejecución 2022. 36. J. Mora, et al; Interventional openlabel, single arm, institutional study to assess Docosahexaenoic acid triglyceride (DHA-TG) supplementation combined with induction chemotherapy in patients with high-risk neuroblastoma; en proceso de ejecución 2022. 37. Ayats, et al Efecto del ácido docosahexaenoico (DHA) antioxidante en pacientes con fibrosis quística. Ensayo clinico aleatorizado doble ciego; finalizado y en redacción para envío a publicar en 2022. 37. Felix Castillo, et al; Caracterización de los niveles de DHA en membrana de eritrocito de grandes prematuros; finalizado y en redacción para envío a publicar 2022. 39. Cristina Peris, et al; Efecto de la suplementación con triglicérido de DHA en el Queratocono; finalizado y en redacción para envío a publicar 2022. 40. Antonio Morilla-Grasa, et al; Effect of Citicoline and Docosahexaenoic acid (DHA) in the visual function of glaucoma patients. Preliminary results ARVO Abstracts; Investigative Ophthalmology & Visual Science July 2019, Vol.60, 2402; en proceso de ejecución 2022.